BIOC39H3 Lecture Notes - Lecture 3: Innate Immune System, Lectin Pathway, Mycobacterium
26 Mar 2020
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Innate immunity i: mechanisms of innate immune defense, the complement system, the alternative, lectin and classical pathways of complement, regulatory mechanism of complement, functional effects of complement. So, they are fought with activated macrophages to help the t cells get rid off those vesicular pathogens: extracellular pathogens are accessible to soluble, secreted molecules of immune system, whereas intracellular pathogens are not. The complement system (a system of plasma proteins that mark pathogens for destruction. Complement activation pathways: classical pathways are only induced upon the initiation of adaptive immune response, first classical pathway, then alternative and then lectin pathways were discovered, all these pathways converge into cleaving. C3 into c3a (recruits immune cells into the tissue) anc3b (bound to pathogen surface and starts opsonisation) Fixation of complement: complements are circulating within the blood, made in the liver. It has high energy thioester sight that is sequestered in the hydrophobic interior of.
