BIOC12H3 Lecture Notes - Lecture 6: Phosphate, Organelle, Fatal Familial Insomnia
23 Sep 2016
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Lec06 lecture outline: protein folding, protein complexes. 1. consists of alpha and beta protomers a. tetramer subunits come together to form subunit (heme) binding sites b. substrate is oxygen schematic diagram of an immunoglobulin (igg) A cross link is a bond that links one polymer chain to another c. i. 1. b. They can be covalent bonds or ionic bonds c. i. 1. c. Proteins naturally present in the body can contain crosslinks generated by enzyme catalyzed or spontaneous reactions c. i. 1. d. Cross links are important in generating mechanically stable structures such as c. i. 1. d. i. Disulfide bond formation is one of the most common cross links: metal ions can stabilize structure hydropathy plot of bovine chymotrypsinogen, hydrophobic interior of protein, hydrophilic exterior of protein. 3. classic role of zinc in the structure of the "zinc finger" structure which is critical in protein-protein interactions, a class of transcription factors.
