BIOC19H3 Lecture Notes - Lecture 3: Phosphatidylserine, Nucleated Red Blood Cell, Erythropoietin Receptor
5 Nov 2017
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Nucleus in final differentiated cell in ave, birds + fish -- > condense. Final differentiated rbc circulating in body has no nucleus. Humans expelled nucleus in final differentiated cell. Extreme differentiated human final rbc no nucleus. In other species birds, fish, amps circulating rbc has nucleus but highly condense. Shape of mature human rbc (called an erythrocyte: simple cells: no organelles, no nucleus, only plasma membrane, cytoskeleton and cytoplasm, 95% of protein content is hemoglobin, biconcave shape, nucleus lost during development of red blood cell. Not sphere disc shaped, one side has concave depression. Differentiated human rbc = simple cell bc if we look inside no organelles like mitochondria or golgi in fully differentiated cell. Human erythrocytes (mature rbcs) are constantly spinning, tumbling, flexible and squeezing through large and small blood vessels in all tissues of the body. To do this to get through small blood cells, differentiated rbc has to be flexible has to twist and turn without breaking.
