BIOC19H3 Lecture Notes - Lecture 6: Thanatophoric Dysplasia, Stat5, Smoothened
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Morphogen gradient: when the amount falls below a certain threshold it stops secreting, xbra gene is a transcription factor for (low activin is muscle development). In order to stop the signal, you will have to deactivate gap, the gtp becomes gdp and it stops at the point where the protein binds to ras: can have signal amplification. Involved in regular cell synthesis: stat5 cannot do anything by itself, it has to bind to another stat5 to form a dimer. Wnt pathways: there are 2 types: canonical and non-canonical, the protein that is made gets modified, palmitic acid and palmitoleic acid gets added into the pathway, release pattern is similar to the hedgehog pathway. Canonical wnt pathway: signal coming in, you get multiple protein receptors, signal goes in, one of the first pathway to be discovered. It will lead to changes cell shape and cell polarity. Wnt pathways - summary: these pathways happen in sync, not happening in isolation.