Class Notes (922,511)
CA (542,864)
UTSC (32,932)
BIOD27H3 (56)
Lecture 5

BGYB30H3 Lecture 5 Notes Chemical Synapse 1-Sep 24

1 Page
127 Views

Department
Biological Sciences
Course Code
BIOD27H3
Professor
Ingrid L.Stefanovic

This preview shows half of the first page. Sign up to view the full page of the document.
BGYB30H3 Lecture 5 Notes
-graded potentials occur in the cell body and dendrites
-action potentials occur in the axon (particularly the axon hillock)
-chemical neurotransmission occur in the synapse of the neuron
-neurotransmission is the conversion of the action potential into a chemical signal, which induces a
response in the target
-chemical signal could be a neurotransmitter
-pre-synaptic bouton is located near the post-synaptic junction (synaptic cleft in between)
-post-synaptic junction contains voltage gated channels of sodium and potassium
-pre-synaptic bouton contains calcium channels
-before a synapse, the action potential depolarizes the axon terminal by opening calcium channels and
calcium enters the bouton
-calcium triggers exocytosis of synaptic vesicles that release neurotransmitter
-neurotransmitter binds with receptor on post-Çv]oovZdownstream response[oo
signal transduction
-neurotransmitter remains outside the post-synaptic cell
-signaling cascades are activated by different types of receptors which are ionotropic receptors and G-
protein coupled receptors
-ionotropic receptors (ligand gated) are coupled to an ion channel
-ionotropic receptors cause movement of ions across membrane through ion channel when
neurotransmitter binds to them (creates a fast response)
-in G-protein coupled receptors, neurotransmitter causes activation of receptor, which activates G-
protein (creates a slow response)
-signal is amplified once receptor is activated because G-protein signals amplifying enzymes that signal
secondary messengers
-secondary messengers are the initiators of responses in the cell
-ionotropic and G-protein coupled receptors alter the open state of voltage gated channels by closing
the channel to alter membrane potential
-less sodium inside the cell causes IPSP, less potassium outside the cell causes an EPSP
-secondary messengers modify existing proteins and synthesize new proteins, which are referred to as
co-ordinated cellular responses
-after synapsis, neurotransmitters are transported back to presynaptic cell where they are packed into
vesicles again and transported to a reserve pool of synaptic vesicles
-the active zone is the region where the exocytosis of neurotransmitters occurs
-calcium binds to calcium sensitive proteins on vesicles before exocytosis occursn
www.notesolution.com

Loved by over 2.2 million students

Over 90% improved by at least one letter grade.

Leah — University of Toronto

OneClass has been such a huge help in my studies at UofT especially since I am a transfer student. OneClass is the study buddy I never had before and definitely gives me the extra push to get from a B to an A!

Leah — University of Toronto
Saarim — University of Michigan

Balancing social life With academics can be difficult, that is why I'm so glad that OneClass is out there where I can find the top notes for all of my classes. Now I can be the all-star student I want to be.

Saarim — University of Michigan
Jenna — University of Wisconsin

As a college student living on a college budget, I love how easy it is to earn gift cards just by submitting my notes.

Jenna — University of Wisconsin
Anne — University of California

OneClass has allowed me to catch up with my most difficult course! #lifesaver

Anne — University of California
Description
BGYB30H3 Lecture 5 Notes -graded potentials occur in the cell body and dendrites -action potentials occur in the axon (particularly the axon hillock) -chemical neurotransmission occur in the synapse of the neuron -neurotransmission is the conversion of the action potential into a chemical signal, which induces a response in the target -chemical signal could be a neurotransmitter -pre-synaptic bouton is located near the post-synaptic junction (synaptic cleft in between) -post-synaptic junction contains voltage gated channels of sodium and potassium -pre-synaptic bouton contains calcium channels -before a synapse, the action potential depolarizes the axon terminal by opening calcium channels and calcium enters the bouton -calcium triggers exocytosis of synaptic vesicles that release neurotransmitter -neurotransmitter binds with receptor on post-ZL] ooL ZZdownstream response[ oo signal transduction -neurotransmitter remains outside the post-synaptic cell -signaling cascades are activated by different types of receptors which are ionotropic receptors and G- protein coupled receptors -ionotropic receptors (ligand gated) are coupled to an ion channel -ionotropic receptors cause m
More Less
Unlock Document


Only half of the first page are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


OR

Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit