Class Notes (905,041)
CA (538,335)
UTSC (32,636)
BIOD27H3 (56)
Lecture 7

Lecture 7

24 Pages
47 Views

Department
Biological Sciences
Course Code
BIOD27H3
Professor
Ingrid L.Stefanovic

This preview shows pages 1-3. Sign up to view the full 24 pages of the document.
Type of neurotransmitter released from axon bouton defines the type of
neuron
e.g Dopaminergic neurons release the neurotrasmitter (NT) _dopamine_(DA)
_(nor)adrenergic_ neurons release the NT noradrenaline (norepinephrine)
Cholinergic neurons release _acetylcholine________________
NT can be released into the blood stream to causes effects e.g _adrenaline_
Different types of R are located in different regions of the body
GABAergic and glutamatergic Rs are found _all over the brain________
High levels of dopaminergic Rs are found high in the _areas of the brain that
control of moods, personality, motor functions
Cholinergic R are found in _skeletal muscle, brain regions involved in motor
Control, heart___________________________
Adrenergic R located in __heart, intestines and brain____________________
1
www.notesolution.com
Figure 6-7 and 6.9
Signalling Molecules downstream of GPCR
Receptor
Amplifying enzymes
Second messengers
Response
Neurotransmitter
2
www.notesolution.com
Signalling Molecules downstream of GPCR
1. The G protein-coupled adenylyl cylase -cAMP system
STIMULATION =Gs
Fig 6.11 -slide 1
3
GPCR
NT
GP
Amplifying enzyme
Second messengers
kinases
intracellular
proteins
IC
EC
membrane Used for receptors of
androgenic : b1 +b2+b3 or
Dopaminergic: d1
www.notesolution.com

Loved by over 2.2 million students

Over 90% improved by at least one letter grade.

Leah — University of Toronto

OneClass has been such a huge help in my studies at UofT especially since I am a transfer student. OneClass is the study buddy I never had before and definitely gives me the extra push to get from a B to an A!

Leah — University of Toronto
Saarim — University of Michigan

Balancing social life With academics can be difficult, that is why I'm so glad that OneClass is out there where I can find the top notes for all of my classes. Now I can be the all-star student I want to be.

Saarim — University of Michigan
Jenna — University of Wisconsin

As a college student living on a college budget, I love how easy it is to earn gift cards just by submitting my notes.

Jenna — University of Wisconsin
Anne — University of California

OneClass has allowed me to catch up with my most difficult course! #lifesaver

Anne — University of California
Description
‡ Type of neurotransmitter released from axon bouton defines the type of neuron e.g Dopaminergic neurons release the neurotrasmitter (NT) _dopamine_(DA) _(nor)adrenergic_ neurons release the NT noradrenaline (norepinephrine) Cholinergic neurons release _acetylcholine________________ ‡ NT can be released into the blood stream to causes effects e.g _adrenaline_ ‡ Different types of R are located in different regions of the body ‡ GABAergic and glutamatergic Rs are found _all over the brain________ ‡ High levels of dopaminergic Rs are found high in the _areas of the brain that control of moods, personality, motor functions ‡ Cholinergic R are found in _skeletal muscle, brain regions involved in motor Control, heart___________________________ 1 ‡ Adrenergic R located in __hearwww.notesolution.comain____________________ Signalling Molecules downstream of GPCR Neurotransmitter Receptor Amplifying enzymes Second messengers Response 2 www.notesolution.com Figure 6-7 and 6.9 Signalling Molecules downstream of GPCR 1. The G protein-coupled adenylyl cylase - cAMP system STIMULATION =Gs NT GPCR Amplifying enzyme EC membrane Used for receptors of GP IC androgenic : b1 +b2+b3 or Second messengers Dopaminergic: d1 kinases intracellular proteins 3 www.notesolution.com www.notesolution.com Signalling Molecules downstream of GPCR 2. The GP-coupled phospholipase ± DAG and IP3 system NT Amplifying Second EC GPCR enzyme messengers kinasesmembrane IC endoplasmic reticulum intracellular proteins 3 Different signalling Used by receptors: molecules: 1 DAG Adrenergic: a2 2 IP3 3 Ca2+ 5 www.notesolution.com Coupling of receptors to signalling molecules Adrenergic Rs Adrenaline/Noradrenaline ‡ -1, -2, -3: - G protein = Gs , - Activates adenylyl cylase - G protein = Gq - Increases cAMP - Excitatory cellular responses - Activates PLC - Increases DAG, IP3, Ca2+ Dopaminergic Rs - Dopamine ,2: - G protein = Gi ‡ D1: - Inhibits adenylyl cyclase - G protein = Gs - Decreases cAMP - Activates adenylyl cylase - Inhibitory cellular responses - Increases cAMP - Excitatory cellular responses 6 Summary ‡ Synthesis, release and catabolism of different neurotransmitters ‡ Types of neurotransmitters and receptors - Amine Receptors - Amino Acid Receptors - Acetylcholine Receptors ‡ Different locations of receptor subtypes and their function ‡ Types of downstream signalling molecules associated with receptor subtypes - amplifying enzymes - second messengers - downstream effects ‡ Functions of neurotransmitter receptors ‡ Receptors as targets for therapeutics and drug abuse 7 www.notesolution.com Lecture 7: Neuronal Integration 5th October 8 Lecture Outline ‡ Integration of neuronal information - Divergence and convergence - Spatial and temporal summation of graded potentials - Presynaptic and postsynaptic modulation - Learning and memory ‡ Axon guidance in the developing brain ‡ Acute and chronic neuronal damage 9 Neurons communicate via a combination of divergent and convergent signals Convergence collates signals Divergence: one neuron connects with many neurons Figure 8.25 10 Neurons communicate via a combination of divergent and convergent signals 11 Figure 8.25 www.notesolution.com Spatial summation of graded potentials that depolarise the membrane minature excitatory postsynaptic potentials (mEPSPs) 3 depolarising GPs (mEPSPs) mEPSP + mEPSP + mEPSP = Threshold ‡Summation of GP triggered in different location
More Less
Unlock Document


Only pages 1-3 are available for preview. Some parts have been intentionally blurred.

Unlock Document
You're Reading a Preview

Unlock to view full version

Unlock Document

Log In


OR

Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit