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BIOA01H3 (699)

immune system lec.docx

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Biological Sciences
Mark Fitzpatrick

Immune System - Recognizes foreign bodies - Responds with the production of immune cells and proteins - Innate Immunity – present before any exposure to pathogens and are effective from the time of birth, consists of external barriers plus internal cellular & chemical defences’ ex. Skin mucus, secretions. Internal defences: Phagocytic cells, antimicrobial proteins, inflammatory response, natural killer cells - Acquired Immunity – develops after exposure to agents such as microbes, toxins and other foreign substances ex. Antibodies, hummoral response, cytotoxic, lymphocytes defend against infection in body cells, cell mediated response - Lymphocytes è thymus è t-cells - Lymphocytes è bone marrow è b-cells - B-cell receptors – bind to specific, intact antigens - Made up of two identical: heavy chains and light chains - The tips of the chains forms a constant region, which contains a variable reigion becase it’s amino acid sequence varies extensively from one b cell to another - Acquired immunity has three important properties , has receptor diversity, a lack of reactivity against host cells and immunological memory Circulation & Gas
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