BIOA01H3 Lecture : Chapter 12 Introduction

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10 Jan 2011

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Chapter 12: central dogma, transcription & the genetic code. Question 1: which of the following repair mechanism is most likely to be used in a cell that in not dividing: proofreading, mismatch repair, excision repair. In excision repair, damaged nucleotides due to mutagen (ultraviolet radiation, x-ray) are recognized. Wrong nucleotides are excised and complementary nucleotide paired with the strand. This process happens in all cells, not just in dna replication. Proofreading & mismatch repair only occurs in dna replication. Proofreading takes place before & mismatch repair takes place after dna replication. Question 2: of the proteins listed, which of these proteins binds to dna earliest during dna replication: single stranded binding protein, dna polymerase i e. telomerase, ligase, dna polymerase iii. After helicase unzips the dna strands, single stranded binding protein binds to each dna strand, preventing them from annealing. The chronological order of enzyme in dna replication is a. single stranded binding protein, c.

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Please help with some epgenetics! I got partial credite for the answers I put but I'm not sure which ones I got wrong!

1) Match the repair pathway to the type of damage it most commonly repairs.

a. Non-homologous end joining

b. Nucleotide excision repair

c. Mismatch repair

d. homologous recombination

e. photolyse

Choices: double strand breaks, UV-induced photodamage, replication error, spontaneous depurination, 5-methyl cytosine

My answer: a. 5-methyl cytosine, b. UV-induced photodamage, c. replication error, d. double strand breaks, e. spontaneous depurination

2) Match the human diseas to the repair patheay that is deficient that disease. Answers may be used more than once.

a. Hereditary polypsis colorectal cancer

b. Xeroderma pigmentosum

c. Ataxia telangiectasia

d. Fanconi Anemia

Choices: mismatch repair, nucleotide excision repair, double strand break repair, base excision repair, photolyse

My answer: a. mismatch repair, b. nucleotide excision repair, c. mismatch repair, d. double strand break repair

3) ____ (a) is a histone chaperone that is recruited by the PCNA and binds to newly synthesized _____(b).

______ (c) is a histone chaperone that acts during the replication-independent assembly pathway, when _____ (d) is incorporated into chromatin.

______(e) is a thrid chaperone that is recruited to replication forks by the replicative helicase.

My answers: a. CAF1, b. H3 and H4, c. H3.3, d. nucleosomes, e. ASF

lemonchinchilla287

Can methylation of nucleotides play a role in DNA replication?

If so, what role does it play?

Removal of methyl groups from nucleotides is concurrent with the conversion of dNTPs to dNMPs during DNA synthesis.

Lack of methylation on the synthesized DNA strand can be recognized by repair enzymes, thus permitting selective base pair mismatch repair.

Lack of methylation on the parental DNA strand can be recognized by repair enzymes, thus permitting selective base pair mismatch repair on the newly synthesized strand.

Methylation does not play a role in replication.

greenmacaw965

1.Can methylation of nucleotides play a role in DNA replication? _____Yes or No

2. If so, what role does it play? (PICK ONE OF THE 4 CHOICES)

Removal of methyl groups from nucleotides is concurrent with the conversion of dNTPs to dNMPs during DNA synthesis.

Lack of methylation on the synthesized DNA strand can be recognized by repair enzymes, thus permitting selective base pair mismatch repair.

Lack of methylation on the parental DNA strand can be recognized by repair enzymes, thus permitting selective base pair mismatch repair on the newly synthesized strand.

Methylation does not play a role in replication.

amethystgoldfish0

BIOA01H3 Lecture : Chapter 12 Introduction

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