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BIOB10H3 (252)
Lecture

Lecture 4

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Department
Biological Sciences
Course
BIOB10H3
Professor
Rene Harrison
Semester
Fall

Description
100411 Lecture 4LysosomesProtein Sorting Lysosomes and Secretion IN the cis Golgi mannose IS THE TARGETING SEQUENCE residues on lysomal enzymes gets phosphylated Binds of M69 Receptor on TGN Clathrin binds to M69 Receptors on cytosolic face Vesicles pinches off containing lysosomal enzymes Fuses w late endosomesbecomes lysosmes M6P receptors recycled1 Cell Disease Lysosomal enzymes secreted Missing enzyme responsible for mannose phosphorylationLysosomes Animals cells digestive organellecontains 50 different hydrolytic enzymes made in RER Enzymes are acid hydrolases function at acidic pH and can hydrolyze every macromolecule Ranges in size from 25 nm1 um in diameter Lysosomes are acidic 0 they have many p
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