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Lecture 6

BIOB10 Lecture 6.docx

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University of Toronto Scarborough
Biological Sciences
Rene Harrison

BIOB10 Lecture 6 FRAP track diffusion of membrane proteins transport across plasma membrane non polar substances small substances can move through the bilayer facilitated diffusion is for large polar molecules go through transporters proteins that carry facilitated diffusion high to low concentration active transport requires ATP to push things across their concentration gradient low to high endocytosis bringing things in to destroy them hydrolyze breaks up macro moleculesendocytosis is for substances that are too large Includes extracellular ligands signal receptors that are no longer in use endocytosis and phagocytosis diff is size Phagocytosis uptakes larger particles endocytosis main time is Receptor Mediated Endocytosis uptake of specific extracellular macromolecules steps ligand binds to the receptor induces a conformational change that tells clatherin thers something needs to be brought in forms an early endosome brought in the ligand clatherin falls off Slow acidification causes the insulin to no longer have affinity to the receptor So the receptor pinchs off and the insulin keeps going the clathrin vesicles arent big enough for bigger particles phagocytosis is used in unicellular eukaryotes amoeba internalizing another prokaryote endosymbiosis have capacity to target particles larger than themselves and inter
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