Bio B11 L19 C16 The Biology of Cancer
Fig 16-3: Growth properties of normal and
cancerous cells: (a): Normal cells typically grow in a culture dish until they cover the surface as
a monolayer. (c): cells that have been transformed by viruses or carcinogenic chemicals (or
malignant cells that have been cultured from tumors) typically grow in multilayered clumps, or
foci. Fig 16-4: The effects of serum deprivation on the
growth of normal and transformed cells. Whereas the growth of cancer cells continues
regardless of the presence or absence of exogenous growth factors, normal cells require these
substances in their medium for growth to continue. The growth of normal cells levels off as the
growth factors in the medium are depleted.
Aneuploidy: An abnormal # of chromosomes.
Elevated proteinases break down the ECM allowing
cells to detach and metastasize (INVAAAAADE!) In the news today: breathing is linked to all forms of
cancer! oh noes!
Fig 16-6: Changing cancer incidence in persons of
Japanese descent following migration to Hawaii. The incidence of stomach cancer declines,
whereas that of breast and colon cancer rises. However of the three types of cancer, only colon
cancer has reached rates equivalent to Caucasian Hawaiians by the second generation. ... I don't have this damn figure. Basically as you
age, the tiny mutations that slip through the DNA repair / checking mechanisms accumulate and
the incidence of cancer increases.
Fig 16-19: The Genomic landscape of colorectal
cancers: These 2D maps