Chapter13: The Science of Risk Assessment:
The basic model, partitions risk assessment into four steps: hazard identification,
dose-response modeling, exposure assessment and risk characterization.
Integration of a risk assessment with a cost analysis and other matters to develop
strategies for risk regulations and control often called risk management
Hazard identification uses the input of biologist, chemist and others to determine
whether available data indicate that some compound or exposure should be
considered possible hazards.
Dose-response modeling requires the input of statisticians, epidemiologist and
people expert in developing models that predict adverse response as a function of
Toxicologists are important for understanding mechanism of toxicity and the
relevance of animal data for human exposures.
Exposure measurements often require the input of engineers as well as hydrologist
(for waterborne hazards), meteorologists (for airborne hazards). And analytical
The risks associated with exposures to a hazard may be expressed by a variety of
summary satisticans that include individual life time risk, annual population risk,
the percentage or proportion of increase in risk and loss of life expectancy.
Six essential issues arise in risk assessment. First, not every person exposed to a
potential hazard will exhibit an adverse response. In addition, almost every adverse
response to so