BIOB32H3 Lecture Notes - Lecture 8: Protein Kinase A, Excitatory Synapse, Resting Potential
5 Nov 2017
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The story of what happened next to tim: (cid:862)fro(cid:373) be(cid:374)(cid:272)h to beside(cid:863) . How studies in the laboratory impact patients and. Parki(cid:374)so(cid:374)"s disease a(cid:374)d l-dopa-induced dyskinesia: slowness of movement, resting tremor, muscle rigidity. Research (cid:862)a (cid:374)ovel mdma a(cid:374)alogue, uwa-101, that lacks psychoactvity and cytotoxicity, enhances l-dopa benefit in parkinsonian primates. Mdma street drug works by increasing 5ht serotonin levels. Interested in manipulating the molecule to have beneficial effects without the side effects. Is there a role for e(cid:272)stasy i(cid:374) the treat(cid:373)e(cid:374)t of parki(cid:374)so(cid:374)"s disease: no. Raises core temperature can be lethal. Others e. g. toothwear: however, ecstasy illustrates the potential of manipulating 5-ht transmission in. Fi(cid:374)di(cid:374)g (cid:271)etter treat(cid:373)e(cid:374)ts for parki(cid:374)so(cid:374)"s disease reduction of side effects. Took mdma chemical and manipulated it with diff compounds. Mdma and mdma analogues decrease dyskinesia in a primate model of parki(cid:374)so(cid:374)"s disease. Show effect of diff chemicals on dyskinesia. Rating scale to be performed on primates. Good on time when they have beneficial effects on l-dopa.
