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Lecture 18

Lecture 18 on Muscles Part II

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University of Toronto Scarborough
Biological Sciences

BIOB30Fall2011 Lecture 18 Muscles II Molecular Basis Of Contractionoo Rigour State No ADPATP occupies second binding site o Myosin heads tightly bind to Gactino 1 ATP binds to myosin which decreases affinity of myosin for actino Myosin releases actin o 2 Myosin hydrolysases ATP o ADP and Pi remain bound to myosinprovides energy for myosin head to rotate and reattach actin 13 molecules towards the Mlineo Newly formed actinmyosin bridge is weak because troponin is partially blocking myosin binding site o Myosin head cocked full of potential energy o Most usual state of muscle fibreso 3 Power stroke begins after Ca2 bind to troponin to uncover rest of myosin binding site o Cross bridge becomes a tight bond myosin releases Pi allowing myosin head to swivel o Myosin head swings towards Mline sliding the attached actino 4 Myosin releasing ADP marks the end of the power strokeo Myosin binds tightly to actin in rigour state o Rigor state is brief 1
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