BIOC13H3 Lecture Notes - Lecture 6: Phosphofructokinase 2, Phosphofructokinase 1, Glycolysis
5 Feb 2018
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Reactions of glycolysis: phosphoglucoisomerase, phosphoglucoisomerase converts glucose into its structural isomer fructose, g6p becomes f6p. Reason #1 for g6p f6p: this makes phosphorylation easier to occur in fructose requires less energy, there"s also a physical hindrance to using glucose since the oxygen is closer to. In fructose, oxygens are much further from the ring than they are in glucose the ring: reaction of adding another phosphate is therefore quicker and more favourable for f6p. In high [atp], there is then a lower enzymatic activity. Midterm 1: amp can override this atp inhibition amp is an activator, at high work, levels of amp increase drastically while level of adp and. Atp do not change much: amp can then bind to the allosteric site, further activating the enzyme and more atp is made. If done with g16bp (ie. never converted to f6p), wouldn"t get 2 isomers: conversion to fructose prevents the need for 2 separate metabolic pathways to breakdown the molecules.
