BIOC14H3 Lecture Notes - Lecture 9: Chemotherapy, Tumor Suppressor Gene, Petri Dish
1 May 2014
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Environmental epigenetics: mechanisms above gene expression like dna methylation or histone modifications, can have stochastic changes in epigenetic cells that accumulate, some epigenetic mechanisms can be directly acted upon by env factors, psychiatric diseases. 2 identicaly genes (dna seq: 1 case modified cytosines in promoter region. 03/27/2014: 2nd case methylated cytosines in promoter regions. Don"t know about risk factors for schizophrenia. Part 2: human genome has less genes than plants, but we"re more complex species. Genes knew where they came from, must be a tag or imprint on that chromosome (diff genes were being silent) Something other than genes that can control them directly were being passed on. 1 twin is normal and other twin has cancer. Is there a mark that remembers it: less nurtured rats had multiple less active genes, stress levels soared, nurtured rats can better handle stress bc nothing diminishing their activity. Take drugs to silence tumor suppressor genes.
