BIOC15H3 Lecture Notes - Lecture 3: Phenylalanine Hydroxylase, Frameshift Mutation, Nonsense Mutation
16 Dec 2013
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Typically how we encounter today via mutant (forensic data/paternity identification) First step, ask the base pairs of dna missing results in the absence of phenylalanine (phe) at the position 508 phenylalanine is f phenylalanine (phe) Using the table p. 248 single letter code . Change in position that results in the absence of. Mutations classified by their effect on dna. Transition: purine for purine or pyrimidine for pyrimidine. Transversion: purine for pyrimidine or pyrimidine for purine. Delta f508 was a deletion; whole chink of dna is missing. Mutations are classified how dna is disrupted; first definition of mutation. Change at dna that leads to differences in mrna that leads to differences in polypeptide. For other hemoglobins, you can do the same thing. Mutation will change the mrna that changes the polypeptide it is coded for. What is happening at the dna level at the template strand and how a translation is being changed with the triplet codon.
