lec on bone

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University of Toronto Scarborough
Biological Sciences
Stefan Rusyniak

Bone Developmenty Two classificationso Intramembranousno cartilage precursor to be replacedFlat bones of skull face mandible and clavicle develop this way o Endochondralreplacing cartilage skeleton with bone see this in maturing boneTypically the bones of extremities axial bones that bear weightlike the vertebrae form this way y Keep in mind they both form the same TYPE of bone this classification only describes the mechanism of bone formationwhen naming bone can either use type of bone or mechanism as prefix ex intramembranous ossifintramembranous boneIntramembranous Ossification y Bone is formed by differentiation of mesenchymal cells into osteoblasts y Process o Initiating step in IOssif Palestaining elongated MCs migrateaggregate in areas where bone supposed to develop o MCs diff into osteoprogenitor cellsthese cells express Cbfal transcription factoro New tissue at bone site becomes vascularised mesenchyme cells become larger and rounded used to be elongated o Histological changesMCs larger and roundedCytoplasm goes from eosinophillic to basophilicClear golgi area forms o Form a differentiated osteoblastsecrete collagen type 1 osteocalcin and osteoido On slide note tha
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