BIOC32H3 Lecture Notes - Lecture 21: Growth Hormone–Releasing Hormone, Anterior Pituitary, Circadian Rhythm
Document Summary
Insulin like growth factor release from mainly the liver: together igf and gh stimulate bone growth (as well as cartilage growth) and tissue growth. Growth hormone is essential for normal growth in children: severe gh deficiency leads to dwarfism treated with genetically engineered human growth hormone (synthetic version of. Gh to treat dwarfism) inhibition of bone growth also affected by subsequent decrease in igf (not just low. Gh: oversecretio(cid:374) of gh i(cid:374) childre(cid:374) leads to gia(cid:374)tis(cid:373) (cid:894)a(cid:374)yo(cid:374)e taller tha(cid:374) (cid:1010) (cid:1011)(cid:895) Tissue and bone growth: tissue and bone growth can occur in two directions, hyperplasia cell division, hypertrophy cell growth, no matter which occurs requires input of gh / igf / thyroid hormone. Lack of any of these cause failure of normal growth least detrimental is thyroid deficiency: thyroid important in neuronal development of the brain, dynamic growth constantly broken down and building up.