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BIOC33H3 (127)

Inflammation and Wound Healing

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Biological Sciences
Stephen Reid

Chapter 13: Inflammation and Wound Healing  The inflammatory response is a sequential reaction to cell injury. It neutralizes and dilutes the inflammatory agent, removes necrotic materials, and establishes an environment suitable for healing and repair.  The basic types of inflammation are acute, subacute, and chronic. o In acute inflammation, the healing occurs in 2 to 3 weeks and usually leaves no residual damage. o Subacute inflammation has the features of the acute process but lasts longer. o Chronic inflammation lasts for weeks, months, or even years.  The inflammatory response can be divided into a vascular response, a cellular response, formation of exudate, and healing.  The vascular response results in vasodilation causing hyperemia (increased blood flow in the area), which raises filtration pressure.  During the cellular response, neutrophils and monocytes move to the inner surface of the capillaries (margination) and then through the capillary wall (diapedesis) to the site of injury.  Exudate consists of fluid and leukocytes that move from the circulation to the site of injury. The nature a
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