BIOC33H3 Lecture Notes - Reuptake, Cytosol, Endoplasmic Reticulum

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2 Feb 2014
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Assignments: just need to submit what is requested in instructions. Cardiac output: amount of blood pumped per unit time, co = sv x hr, map = co x tpr. Helps to speed up the relaxation of the heart when it transitions from systole to diastole. Important because it allows heart to spend more time in diastole - can fill with more blood. Autonomic regulation of heart rate: parasympathetic (vagus) : have our cardiac branch of the vagus nerve that presynaptically releases acetylcholine onto ganglia where it binds to nicotinic receptors. Post-ganglionic cell also releases acetylcholine onto the heart. Acetylcholine interacts with muscarinic acetylcholine receptor (on the heart) From post-ganglionic fibre have ne released as a neurotransmitter. Ne speeds up pacemaker potential as well as speeds up conductivity from the av node: adrenal gland. Also under control of sympathetic nervous system. Nt = ach, reacts with nicotinic receptors on adrenal cells and release ne and epinephrine into the blood.

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