BIOC34H3 Lecture Notes - Lecture 6: Skeletal Muscle, Cardiac Output, Blood Vessel

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Effect of pre-load: preload is the stretching of the heart due to increased blood flow in the ventricles, end-diastolic pressure used to measure preload. Edp decreases resulting in decreased sv (not as much blood to pump out) and therefore a decreased cardiac output. In decreased compliance, edv is decreased and esv is also slightly decreased (there is less blood to be pumped: biggest sign = increased edvpr slope. Jan. 24, 2018: relaxation allows for inflow into vein with proximal valve being closed but distal valve is open facilitates preload. Effect of respiratory pump: breathing also drives blood up into the heart via the diaphragm, during inspiration, diagraphm contracts and moves downward. Effect of filling time: filling time is the amount of time available for blood to enter the ventricles, low heart rate = more time in diastole, more time filling, more edv and more sv.

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