BIOC39H3 Lecture Notes - Lecture 4: Proteasome, Aminopeptidase, Antigen Processing

• School: UTSC
• Department: Biological Sciences
• Course: BIOC39H3
• Professor: Bebhinn Treanor

Document Summary

T cell receptor resembles b cell receptor know how to draw the receptors: similar structure resembles single arm of ig, produced by gene rearrangement, highly variable, diverse antigen specificity. See slide 12 for diversity of antigen receptors b vs t cells (higher diversity due to j segs) : heterodi(cid:373)er asso(cid:272)iates (cid:449)ith (cid:1008) i(cid:374)(cid:448)aria(cid:374)t (cid:373)e(cid:373)(cid:271)ra(cid:374)e protei(cid:374)s for (cid:272)ell surfa(cid:272)e expressio(cid:374: cd3 complex, cd(cid:1007)(cid:630) (cid:894)ga(cid:373)(cid:373)a(cid:895, cd(cid:1007)(cid:631) (cid:894)delta(cid:895, (cid:1006)x cd(cid:1007)(cid:632) (cid:894)epsilo(cid:374)(cid:895, (cid:1006)x -chain (zeta, cd(cid:1007) a(cid:374)d -chain contain itams (immunoreceptor tyrosine activation motif) = signal transduction. Tcr + cd3 complex = functional tcr complex. There is a distinct population of t cells with a different tcr. Gamma delta t cells, similar structure otherwise, small proportion of peripheral tissue (localized in the skin, not very well understood) Gamma: delta cells also undergo gene rearrangement: reduced gene segments but two d segments can be incorporated! Increases the potential number of gene segment combinations. Increased junctional diversity p/n nucleotides at dd, vd and dj junctions.