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BIOC51H3 (51)
Lecture 10

BGYB51H3 Lecture 10 Notes Oct 13

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Biological Sciences
Maydianne Andrade

BGYB51H3 Lecture 10 Notes -comparing mitochondrial DNA can be used to determine mutationslocusgeneration -mitochondrial DNA is more susceptible to errors and mutations than nuclear DNA -mutation rates are variable because they depend on the accuracy of DNA polymerase -DNA polymerase varies due to allelic variation and the fact that it is a synthesized protein -mutation is a side effect of rapid cell division, which is a trade off of DNA replication -high mutation rates are favoured in novel environments -low mutation rates are favoured in similar and constant environments -mutation strain is more successful in early infection due to novel environment -when wild type strain adapts to novel environment, mutation advantage stops -wild types eventually slow mutation to reach high level of fitness -any factor that tries to reduce variation is a selective agent -in most cases, strains of w
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