BIOC65H3 Lecture Notes - Lecture 11: Nicotine, Antiseptic, Normal Distribution
23 Dec 2017
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Structure-activity relationship (sar); toxicant entry and efflux; phase-i and phase- Streptococcus viridans- produces transmembrane proteins capable of destroying membranes via creating pathological porins. Dextran formation via glucose + streptococcus viridans form; aggregation of blood and other cells cause blood clot. *note: black tea bags and salt water (?) can help with gingivitis. Elevated t-cell counts; even (0. 0001%) of elevation can be enough to cause the inflammation and infection symptoms. Infection to beta barrel proteins (superantigens) calls in 20-100% of t-cells. Body attacks its own tissue in broad activation of t-cells. Immune cells (cid:272)a(cid:374)"t recognize what is its own or whats foreign. Can lead to death in less than 24 hours. Tends to affect legs more; typical intervention is amputation. Toxins targeting beta barrel proteins call in t-cells (superantigens) so far above the norm broad activation means immune cells (cid:272)a(cid:374)"t differentiate between own and foreign components destroy everything. The couple basics to know to apply to everything else: solubility- (hydrophobic hydrophilic)
