BIOD22H3 Lecture 4: Synthesis
11 Feb 2017
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Document Summary
Hsc70 plays a normal role in synthesis preventing newly synth proteins from mis ling and. Some pla a role in normal pro. synth. After stress normally folded proteins unfolded and become biologically inactive and tend to. And we saw that cells react to stere by inducing a set of stere inducible hsps . In this little review we will mainly be looking at gure one which looks as hsp70 and 40 and. So normally proteins like enzymes are folded in a 3d structure - which creates an active. After stress certain proteins unfold and lose this site and become inactive. So cells can sense stress induced unfolding. The rst player that acts is hsp40 - or dnaj his acts in this machine to direct protein mis ling xing. It can detect mis led proteins and bind to them hsp40 especially the dnaj type speci cally nd and bind to mis led pros. and prevents aggregation.
