BIOD22H3 Lecture Notes - Lecture 1: Protein Folding, Hsp70, Mechanistic Target Of Rapamycin
13 Feb 2018
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Document Summary
Nserc federal agency provides grants (programs for fellowships) Two important things happen simutlatenlously when they expierence stressful stimulti. Turn off gene expression and same time they induce a new set of genes enconding heat shock proteins that works for cellular repair and protection. After stress cells dramatically change how they use energy they are sysntehsizing energy for repair and protection and turn off energy for normal pattern of gene expression. Basic cellular defense mechanism that is present in all cells. Hsp proteins these hsp proteins play roles in cellular repair and protection and the following simpley model explains how the stress induce proteins play role in repair and protection. Portiens have to fold up to form biologically active. What happens after stress the cell in defense turn on the synthesis of heat shock and it can detect and bind to the unfolded proteins and trigger refolding and retaining biologically activity.
