BIOD22H3 Lecture Notes - Lecture 9: Apoptosis, Beta Sheet, Synuclein
Document Summary
Paper: modulation of neurodegeneration by molecular chaperones . They are thought to be neuro- protective because maybe they can target early aberrant confirmations of neural proteins early aberrations are formed at early stages during time course of nd. Understanding mechanisms of how molecular chaperone are neuroprotective therapeutic approaches for treating nd. A range of nd can be termed protein misfolding disorders characterized by intra- or extracellular neuronal aggregates. Few reasons why neurons are particularly vulnerable: one reason is most neurons in the adult brain are post mitotic that is they are no longer dividing can"t dilute toxic substances by cell division. These are some of the reasons neurons particularly vulnerable to errors in protein metabolism. Molecular chaperones play a big role in detection and refolding of misfolded proteins. Fig 1 - molecular chaperones regulate many cellular processes . In this box we see quick summary of 6 main types of heat shock hsp families.
