BGYB30H3 Lecture 5 Notes Chemical Synapse 1-Sep 24

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University of Toronto Scarborough
Biological Sciences
Ingrid L.Stefanovic

BGYB30H3 Lecture 5 Notes -graded potentials occur in the cell body and dendrites -action potentials occur in the axon (particularly the axon hillock) -chemical neurotransmission occur in the synapse of the neuron -neurotransmission is the conversion of the action potential into a chemical signal, which induces a response in the target -chemical signal could be a neurotransmitter -pre-synaptic bouton is located near the post-synaptic junction (synaptic cleft in between) -post-synaptic junction contains voltage gated channels of sodium and potassium -pre-synaptic bouton contains calcium channels -before a synapse, the action potential depolarizes the axon terminal by opening calcium channels and calcium enters the bouton -calcium triggers exocytosis of synaptic vesicles that release neurotransmitter -neurotransmitter binds with receptor on post-ZL] ooL ZZdownstream response[ oo signal transduction -neurotransmitter remains outside the post-synaptic cell -signaling cascades are activated by different types of receptors which are ionotropic receptors and G- protein coupled receptors -ionotropic receptors (ligand gated) are coupled to an ion channel -ionotropic receptors cause m
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