BGYB30H3 Lecture 17 Notes Control of Body Movement-Nov 5

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University of Toronto Scarborough
Biological Sciences
Ingrid L.Stefanovic

BGYB30H3 Lecture 17 Notes -the sliding filament model is the mechanism of force generation in the muscle -muscles shorten when they contract -actin and myosin slide past each other during contraction, causing cross-bridge cycling -cross bridge cycling requires energy from ATP to cause contraction and allows tension without movement -at rest, thick and thin filaments in the myofibril overlap slightly -when muscle contracts, Z disks move towards each other -thin filament slides over thick filaments towards the M-line in the center -sarcomere, H band, and I bands shorten during contraction while the A band remains the same -rigor state involves no ADPATP occupying 2 binding site while myosin heads bind to G-actin -when ATP binds to myosin, affinity for actin decreases and actin is released from the binding site -in the second stage myosin hydrolyzes ATP to form ADP and P but tie molecules remain bonded to myosin head in order for it to move and bind to next actin molecule near the M-line -the newly formed bridge between myosin and another actin molecule is weak because troponin partially blocks the myosin binding site -myosin head is full of potential energy, which is the state most muscles are found in -power stroke is the third stage where calcium binds to troponin to cause tropomyosin to open the binding site -the newly formed bridge becomes strong and P is rileased from the myosin head -myosin head s
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