EESA10H3 Lecture Notes - Median Lethal Dose, Molecular Mass, Bioaccumulation

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12 Feb 2013
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During the lecturre we will come on formulas and everything needed on questions 1. Tocicisty of some chemicals basically depends on: chemical characteristics of the poison that are, polarity. Electronegativity: oxidation state: when we talked about arsenic 3 and 5 are different, molecular weight, dissociation, solubility. Water soluble toxins: inorganic chemical dissolve in water, difficult for them human cell. They surround the cell but they don"t enter. Fat soluble toxins: organic chemical are dissolved in fats. Fat soluble cell easily enter the cell, that"s why they bioaccumalate: persistence of chemical: some chemicals can break down easily, some stay persistence for years without much change, bioaccumulation, biomagnification, chemical interaction. Antagonistic effect: one chemical reduces the toxicity of another chemical eg. vitamin a and e might reduce cacogenic effect for some chemicals. Synergistic: 2 different chemicals taken up at the same time by a person increase the risk of a disease eg. smoking and: multiple chemicals food additives, pesticides, air pollution.

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