EESA10H3 Lecture Notes - Lecture 4: Endocrine Disruptor, Thyroid, Adrenal Gland
3 Feb 2018
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Outline: endocrine disrupters, health implications, neurobehavioral implications, chemical body burdens, organochlorine substances, dioxins, ddt, phthalate and bisphenol a. Endocrine disrupters (disrupt endocrine functions: direct effects, blind to hormone receptors, alter the appearance of some genes, changes in the level of production proteins, indirect effects, altering hormone production, altering hormone transport, altering hormone metabolism. Fetus is more sensitive than adults (ex: des, thyroid dysfunction) Endocrine disrupters: health implications: feminization of males, abnormal sexual behavior, birth defects, altered time to puberty, cancer of mammary glands or testes, thyroid dysfunction, thyroid gland produces t3 and t4. If women have low levels of tsh (thyroid stimulating hormones), then levels of t3 and t4 will be low. Endocrine disrupters: neurobehavioral implications: prenatal and early postnatal exposures (before and after baby is born, pcbs (usually impacted on small children): Impaired learning in nonhuman primates: delated psychomotor development, distractibility, poor iq tests, organophosphates, brain development.
