EESA10H3 Lecture Notes - Lecture 5: Ionic Bonding, Covalent Bond, Lead
7 Feb 2020
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Document Summary
Naturally occurring, extracted from the earth, in ore. A tendency to accumulate in select tissues. Toxicity: class b > borderline > class a. Mechanism for toxicity: blocking essential functional groups in proteins or enzymes; proteins can not carry anything, displace other metals (class b, borderline, modifying the active conformation of biomolecules (class b) Resistance - species develop mechanisms, not to uptake metal (eg. pb, lead uptake by plants) Tolerance - the capacity of a species to withstand high level of metals. Metabolic transformations to less toxic forms (methylation of as (less. Toxic than regular as in its unmethylated form ), arsenic in marine biota) Can develop multiple tolerance - cu, pb, zn, cd. Ingestion (soil, food, plants accumulate metals in roots) Mostly accumulate in the liver, bones, and kidneys. The liver is the first on this list because the liver is the detoxifying organ of the body so anything toxic will first go through the liver.
