EESA10 Lecture 5: Heavy Metals and Human Health

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Department
Environmental Science
Course
EESA10H3
Professor
Jovan Stefanovic
Semester
Summer

Description
EESA10 HUMAN HEALTH AND ENVIRONMENTLecture 5 Heavy Metals and Human HealthHeavy metals are found in ores and extractednaturally occurringWide environmental dispersionSome heavy metals can bioaccumulatein liver brain bonesCan be toxic in very low concentrations Classification of metals3 classes A B and C borderline1Class AExamples K Na Mg CaMacronutrientsessential for biological processesTend to form ionic bondLow toxicity but still toxicevery metal is toxic depending on the concentration2Class BExamples Hg T Pb Ag AuNonessential elements for biological processesTend to from covalent bondsVery toxicform solute organometallics3Class C BorderlineExamples Cr Cu As Co Ni Zn Mn FeEssential for biological processes but only in small amountstrace minerals micronutrientsToxicity level is in between Class a and Class Bin order of increasing toxicity Class BClass CClass AMechanism of ToxicityBlocks essential functional groups such as proteins enzymes which prevents the proteins from carrying anythingreceptors are blockedClass B and Class C metals can displace other metalsClass B can modify the active conformation of biomolecules from active to nonactiveCoping MechanismsOrganisms have mechanism to stop the effects of metalsResistancespecies develop mechanisms not to uptake metalsie plants dont take up leadthey are resistantTolerancethe capacity of species to withstand high level of metalsso organisms pick up the metal but it doesnt harm themthey can live normally with it in their systemInternal detoxifying mechanismsBinding to non sensitive compound structuresMetabolic transformations to less toxic forms methilation As in marine biotaCan develop multiple tolerance Cu Pb Zn CdIf plants can tolerate heavy metals it wont enter food chain1
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