EESA10 Lecture 5.docx

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Department
Environmental Science
Course Code
EESA10H3
Professor
Silvija Stefanovic

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EESA10 Lecture 5 – Feb 8, 2011 Some of the heavy metals have a tendency to accumulate in specific tissues – eg arsenic in hair, nails. Some metals in liver, others in bone or brain. We can look for specific metals in certain tissues using this knowledge. Metals are classified in three classes: - Class A – these metals are macronutrients eg calcium found in bones. Very low toxicity, but we don’t say that they aren’t toxic. RULE: any chemical in the environment can be toxic, but the question is what dose is toxic? - Class B – not essential to physiological processes e.g. lead, mercury. Some of the most toxic chemicals known. - Borderline – essential for some physiological processes, but not in large amounts (micronutrients) such as copper, zinc, iron. In terms of toxicity, they are in between A and B. Mechanism of Toxicity - Mess up the function of carrier or receptor protein. - Displace other metals that are not as toxic e.g. chromium replacing calcium. (Borderline or B class metals do this). - Some organic molecules have different conformations. The metals can change the conformation of some biomolecules from the active into the inactive form (class B metals do this). Coping Mechanisms: - Resistance – No uptake of the metal. Plants don’t take up lead, even if there is a high concentration in lead. There are species that can live normally even though there is lead in the soil. - Tolerance – take up the metal, but can live with it inside us (can tolerate it). Able to withstand high levels of a metal. Metal binds somewhere where it doesn’t make a problem or doesn’t disrupt a process. Or, the metal can be converted to a non toxic or less toxic form. E.g. arsenic is very toxic in inorganic form, not too toxic in organic form. This is important in marine environments, where the arsenic gets converted into its organic form. Plants can tolerate many different metals. Bioavailability of Metals: - Not everything that we inhale, ingest, etc. will be the amounts that cause a toxic effect. We take up much more than the receptors in our body pick up. We take up a higher amount than needed to cause a problem. Why? Because we can excrete/metabolize some of the toxins. If we intake 100 ppm of a substance, the receptors in our body won’t pick up 100. Maybe only 80, for example. - Bioavailability ranges from 0-100, where 0 means it is not bioavailable at all. If bioavailability is low, toxicity is low. Elements with a valence of 0 are low bioavailability. Charged substances have higher bioavailability. - Acidic conditions, for most metals, higher bioavailability and toxicity. - Redox: Oxidized forms of metals are usually less toxic (more oxygen). Reduced conditions (less oxygen) where the metal is in the reduced form, is more toxic. Routes of exposure: - Inhalation - Ingestion – of contaminated foods, plants that have accumulated metals. o In plants – highest concentration of the metals are in the roots, then leaves, then finally lowest concentration is in grain (like corn). - Through the skin – one really toxic form of mercury can even go through latex gloves. - When symptoms become obvious, it may already be too late. Mercury: - Liquid (pure) mercury – very difficult/impossible to find in nature. Found in thermometers. Pure mercury is not very toxic. However, it is volatile and can evaporate, and the fumes are toxic. Also toxic if sprayed (emulsion?). - It is toxic in all forms, both inorganic and organic. In marine biota, transforming it into the organic form doesn’t help, it is still toxic (in comparison to arsenic). - Bioaccumulates. High levels found in different kinds of fish. Pregnant women should never eat tuna. For regular people, once a week suggested. Kids, once a month, maybe twice. This applies to other kinds of fish too. - Can result in many symptoms, including madness. Also causes birth defects, such as mental retardation, problems with memory and language. - Minamata disease first found the city of Minamata in Japan. Industries
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