HISC45H3 Lecture Notes - Lecture 1: Harriet Creighton, Genetic Linkage, Null Hypothesis
Document Summary
Bioc15 class 8 september 29, 2017 copyright hasenkampf 2017. At the end of last class we talked about morgan proposing that syntenic genes (those on the same pair of homologous chromosomes) might not sort independently and instead could be linked. Thus ab/ab means that one parental type was ab and that the chromosome of one parent had. Ab, and the other parental type was ab and the chromosome of the other parent had a b on it. The cross was done in coupling and the dihybrid is called a cis-dihybrid. A cis-dihybrid has all of the wild type alleles on one chromosome and all of the mutant alleles on the other chromosome. If one parent had only the wild type alleles and the other only had mutant alleles we say the cross was done in coupling and the dihybrid is a cis-dihybrid. A trans-dihybrid has at least mutant allele on each of the homologous chromosomes.
