May have come from other pox related disease. Earliest evidence was on egyptian mummies: pharaoh ramses v, had pox marks. Plague of antonine is suspected to be the first epidemic of small pox. We"ve been hearing it since 5th century but several epidemics were reported near 12th centuries. Plague of antonine the fall of the roman empire, believed to have started in. Mesopotamia and thought to have come in through the returning soldiers to italy. New world in the 16th century, introduction of the spanish and portuguese led to the fall of the aztecs and the incas due to the susceptibility. During colonization to the settlement of n. america by the french and english people, the colonization made it easier to spread small pox and set off an epidemic on the indians. Deliberately use of smallpox to win the war in the french-indian war, and smallpox infected blankets were used to win the war.