1494 king charles viii of france invades italy. Outbreak of a new epidemic in naples. Following year mysterious affliction reported in england, france, germany Columbus return from the new world to europe. Was contagious, happened when a man was with unclean woman. 1530 epic - syphilis sive morbus gallicus ( syphilis or the french disease ) Poem about a shepherd boy named syphilus who insulted a god and was punished by that god with a horrible disease. The french disase , italian disease , spanish disease , great pox etc depend on location. John hunter (1728 - 1993) founder of sugergy. Undertook flawed self-experimentation by injecting himself with material taken from a patient with gonorrhea. He developed the signs of syphilis and concluded the two infections were the same. He eventually died of heart problem (tertiary syphilis) Demonstrated that gonorrhoea and syphilis were different disease. Determined the 3 stages - primary, secondary, and tertiary - of syphilis.