HLTB21H3 Lecture Notes - Lecture 6: Smallpox Vaccine, Cowpox, Ramesses V

38 views9 pages
Published on 13 Apr 2013
School
Department
Course
Professor
HLTA01 Lec6 Smallpox 12/02/2013 7:20:00 AM
Origin of smallpox
Indiscriminate disease
Earliest evidence Egyptian mummies
o In the face of mummies
o Pharaoh Ramses V died 1157BC
Describe in ancient Chinese and Indian texts
430BC- plague of Athens (overcrowded)
o they are locked in the city
o ship brought in disease
166AD plague of Antonine
Europe- frequent epidemic
o High mortality rate
o 16th century became a serious disease in England and Europe
Smallpox and the Americas
New world in the 16th century- fall of the empires of the Aztecs
and the Incas
o It wipe out the entire city 50% mortality rate
o Many people from Europe have lifetime immunity but not for
the Incas and Aztecs
o Large religious and societal breakdown
Contributed to the settlement of N America by the French and
English
Smallpox Morbidity/Mortality
20th century
o 300-500 million death
1950
o Estimated 50 million cases per year
Smallpox endemic countries
More in warmer country even though the virus itself are more
sensitive in sunlight
Majority of the disease decrease in the 1920s
At 1959 resolution of global smallpox eradication, most went low
except Africa
At 1967- mostly in Brazil and Africa
Etiology
Pathogen: orthopoxvirus
Unlock document

This preview shows pages 1-3 of the document.
Unlock all 9 pages and 3 million more documents.

Already have an account? Log in
o Variola major : chicken pox, cow pox all have the same
o Ordinary 90%, modified, falt and hemorrhagic
o There’s different version
Modified
90% of the cases
Flat 5-10% cases mostly children
Flat to the skin
A lot are more internal
Hemorrhagic
Black pox
Bleeding under tissue
Bleed from their eyes and bleeding gum
o Vaiola minor
Milder variation
Cross immunity
Anything from the major will have lifetime immunity
Mortality Rates
“Natural” smallpox 20-30%
Modified ≤1%
Flat or hemorrhagic nearly always fatal
Variola minor ≤1%
There is NO treatment for smallpox
Clinical Symptoms
Unlock document

This preview shows pages 1-3 of the document.
Unlock all 9 pages and 3 million more documents.

Already have an account? Log in
spread of smallpox are different-> how it can be diagnose
fever can be really high from 101-104
after rash start it’ll start to form pox
o spread and scab from 5-10days
9th days of rash pustule rash
pustules have reached maximum size and are started to flatten
13th day of rash
Lesions and scabs
Lesions are now scabbing.
20th day of rash
Scabs resolved
The scabs have separated, leaving depigmented areas.
Social implication
Women will not be able to marry if they are disfigured
Slave trade- slave that are expose will be more susceptible
Smallpox are mistake for measles and syphilis and chickenpox
because of the rash
Chickenpox are more on the torso while smallpox are everywhere
Transmission
Prolonged face-to-face contact (respiratory)
Unlock document

This preview shows pages 1-3 of the document.
Unlock all 9 pages and 3 million more documents.

Already have an account? Log in

Document Summary

Earliest evidence egyptian mummies: in the face of mummies, pharaoh ramses v died 1157bc. Describe in ancient chinese and indian texts. 430bc- plague of athens (overcrowded: they are locked in the city, ship brought in disease. Europe- frequent epidemic: high mortality rate, 16th century became a serious disease in england and europe. Contributed to the settlement of n america by the french and. 1950: estimated 50 million cases per year. More in warmer country even though the virus itself are more sensitive in sunlight. Majority of the disease decrease in the 1920s. At 1959 resolution of global smallpox eradication, most went low except africa. At 1967- mostly in brazil and africa. Pathogen: orthopoxvirus: variola major : chicken pox, cow pox all have the same, ordinary 90%, modified, falt and hemorrhagic, there"s different version. Bleed from their eyes and bleeding gum: vaiola minor. Anything from the major will have lifetime immunity.

Get OneClass Grade+

Unlimited access to all notes and study guides.

YearlyMost Popular
75% OFF
$9.98/m
Monthly
$39.98/m
Single doc
$39.98

or

You will be charged $119.76 upfront and auto renewed at the end of each cycle. You may cancel anytime under Payment Settings. For more information, see our Terms and Privacy.
Payments are encrypted using 256-bit SSL. Powered by Stripe.