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Lecture 10

lecture 10

3 Pages
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Department
Health Studies
Course Code
HLTB21H3
Professor
Caroline Barakat

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L10
Plagues without germs/Influenza
Æ
deficient diseases - 'Hidden hunger' diseases
- some date back to the 15th century
- most are specific to the 19th century -- time when the 'germ theory' won the battle
- 'one germ, one disease' theory
Æ
Pellagra - 'Red Plague'
- red rash on the neck, the body
- first described in Ppain in 1735
- pelle agra - Italian for 'skin rough'
- appears first as a skin rash, skin then crusts and peels away
Clinical symptoms -- 4 Ds: dermatitis, diarrhea, dementia, death
- 1909
Æ
epidemic in the US, reported in 26 states
- 1912
Æ
high fatality rates, 40% in South America
- 20th century
Æ
3 million cases in the US and 100 000 deaths
- belief that pellagra was an infectious disease specific to the poor
- by 1939, evidence established that disease was due to niacin-deficiency (a water
soluble B vitamin - vitamin B3)
- niacin needed for normal oxidative metabolism of sugars
Æ
bread enrichment
Æ
1943 - less than half of original deaths, 1948 - mandatory enrichment in 22 states
Æ
Beriberi - 'White rice' plague
- 1616 as a neurological disorder characterized by paralysis of the hands and feet
- 'kakke' meaning 'leg disease'
- white rice -- observed to be related to an increase in prevalence of beriberi
- early 1900s -- Eijkman (Dutch scientist) established that the disease is not germ-
related
- fed polished/unpolished rice to chickens as an experiment
- 1926, deficiency in vitamin B1 (thiamine)
- thiamine is necessary for the normal cell metabolism of sugars and alcohol
- deficiency leads to malfunction in cell activity and cell death
Æ
1942, British commander in Singapore surrendered to the Japanese
Æ
50 000 allied soldiers became POW and were used to build a railway
Æ
Scurvy - 'Explorers' disease'
- earliest record at the end of 15th century
- related to sea exploration (long ocean voyages) - 'plague of the sea'
- mid to late 18th century - disease was related to nutrition and lemon juice intake
which was adopted as a practice in seamen
- James Lind (English naval surgeon) played an instrumental role
Æ
keeping lemon
juice on board
- 19th century - outbreaks of scurvy on land - Ireland, California, New York
- led to the identification and synthesis of vitamin C (1920s and 1930s)
- vitamin C deficiency shuts down the synthesis of collagen (a major component of
connectie tissue found in tendons and ligaments and in the walls of blood vessels)
Æ
weakness and death
Æ
Rickets
- endocrine
- old disease that became an epidemic after industrialization in England after 1650
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Description
L1 0 Plagues w itho ut germ sI nfluenza deficient dise ase s - Hidd en hun ger dise ases - som e date back to the 15 thcentury th - most are spe cific to the 19 century -- time when the germ theory won the battle - one germ, one disease theory Pellagra - Red Plague - red rash on the neck, the body - first described in Ppain in 1735 - pelle agra - Italian for skin rou gh - appe ars first as a skin rash, skin then crusts and peels away Clinical symptoms -- 4 Ds: derm atitis, diarrh ea, dementia, death - 1909 epidem ic in the US, reported in 26 states - 1912 high fatality rat es, 40% in South America - 20 thcentury 3 million cases in the US and 100 000 deaths - belief that pellagra was an infectious disease specific to the poor - by 1939 , evidence established that disease was due to niacin-deficiency (a water soluble B vitamin - vitamin B3) - niacin needed for norm al oxidative metabolism of sugars bread enrichmen t 1943 - less than half of original deaths, 1948 - mandatory enrichment in 22 states Beriberi - White ri ce plague - 1616 as a neurological disord er charac terized by paral ysis of the hands and feet - kakke meaning leg disease - white rice -- observed to be related to an increase in prevalence of beriberi - early 1900s -- Eijkman (Dutch scientist) established that
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