HLTB21H3 Lecture Notes - Lecture 11: Middle East Respiratory Syndrome, Case Fatality Rate, Multiple Organ Dysfunction Syndrome
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Could be more virulent than sars: patients suffer multiple organ failure, esp. renal failure; pneumonia. Novel sars-like coronavirus in the middle east: mar. ), and individuals with co-morbidities -> because it was mostly men doing pilgrimages; they were also older. > imp. factors: pre-existing conditions (esp. diabetes, kidney disease) and a degree of immunosuppression. > resulted in a lower case rate than sars. However, some have been critical about the relatively slow rate of knowledge gathering compared to sars: we still don"t know much about mers. Approaches to controlling emerging and re-emerging infections: primary prevention: modification of, or elimination of, risk factors, secondary prevention by early clinical recognition, rapid laboratory definition and prompt intervention; effective global surveillance is fundamental (see. Quorem sensing: with recognition of inter-bacterial communications, research on substances inhibiting cell-to-cell communication; production of antimicrobials that are less prone to the emergence of resistance. Genomics: improved understanding of bacterial genomes; re: bacterial evolution, potential virulence genes.
