HLTB21H3 Lecture Notes - Lecture 8: Measles Virus, Measles Vaccine, Exanthem

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7 Nov 2011
Lecture 8
test is on: small pox, measles, malaria
people could not distinguish between other rash diseases
-people get diseases at a different severity and virulence
-early description of measles: differentiated small pox and measles and thought they
came from the same cause
-disease was welcomed as a way to get rid of the ʻso called poisonsʼ
modern history dates to the 16th and 17th century
-clearly separated measles from small pox and recognized other related complications
-out of 10children, 8 out of 10 got measles from blood transmission and it was then
recognized as being transmitted through contagion
encephalitis is not just related to measles... also related to herpes, chicken pox, west
nile virus
-can occur during or after infection; not just restricted to measles (years later)
-cancrom orus or norma: destruction of the tissue around the mouth and nasal cavity
peter panum- directed by the danish government to conduct the first epidemiological
study; about 7800 inhabitants and 102 died of measles; 17 isolated islands
-features important to the island: consists of difference terrain, mountains, cool
temperature, clusters of houses, only way to go through one cluster to the other is
through the sea
-specifically, because of the closeness of the inhabitants, the arrival of any boat was
noted and welcomed
-people gathered together when new visitors arrived
-visits from danish mainland was rare but documented
-seaman from Copenhagen infected the population
-followed the course of the epidemic from island to island through boats
four important facts were discovered by peter
-transmission occurs the most 3 to 4 days before rash appears
-contagious through the respiratory route of transmission
1910: hektoen- virus is present in the blood
1963: enders- isolated virus and produced vaccine for it
-1 in 100 000 people develop sub-acute sclerosing panencephalitis about 5 to 10
years after acute measles
-disease of the respiratory system
-transmitted from nose and throat secretions- direct
-very contagious
-records of getting infected when people enter the room where people with measles
were in
-lives for a short period of time on droplets of air
-four days before until four days after rash are the highest periods of infectivity
-virus does not survive on dry surfaces
-humans are the only host
-persistence of measles depends on how many humans have measles in the
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