HLTB21H3 Lecture Notes - Tuberculosis, Papaya, Rudolf Virchow
Document Summary
Most commonly associated with lungs but can affect almost any tissue or organ. Chronic disease lingers for months and sometimes years. Acute forms that commonly strikes infants and children can be fatal in matter of weeks/days. Acute form military tuberculosis has small grainlike tubercles that create simultaneously in almost every organ of body. Ancient times tuberculosis had low prevalence rate. After industrialization, prevalence went up between 18th and 20th century. 2 more drugs: para-aminosalicyclic acid (pas), and isoniazid (inh) discovered in 1946 and 1952. No longer epidemic, but still affect people worldwide from most industrialized countries b/c of higher risk of disease when malnourished or old. Tubercle bacillus is necessary but not only condition for causation. The host and environment contribute numerous other causes central to its pathogenesis. Of animal forms, only bovine can infect people: some bacteriologists consider bovine separate from tubercle bacillus. Human bacillus divided into 2 types according to phage types: type 1: found in india.
