HLTB20H3 Lecture Notes - Lecture 2: Zygosity, Panmixia, Allele Frequency

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Week 2 the forces of evolution and mating systems: the fundamentals of human. Consequence an elevated frequency of rare genetic diseases. Trista de cunha: isolated island in the atlantic. Very inaccessible because of harsh weather, location and no natural harbour. Results rare recessive traits and unique gene frequencies (i. e. asthma: natural selection. Mutation, gene flow, genetic drift influence what alleles are present in a population. Natural selection provides directional change in allele frequencies (i. e. alleles can become more/less common) When environment changes, selection pressures change different alleles may be more/less favoured. These functional shifts in allele frequencies = genetic variation and adaptation. Acts to limit and stabilize genetic diversity. Co(cid:374)(cid:272)ept of (cid:862)fit(cid:374)ess(cid:863) measure of an orga(cid:374)is(cid:373)s" ability to survive and reproduce. Can measure fitness of species variants: at the level of differential mortality/fertility. Other forces beside natural selection can shift the proportion of variants (example: gene flow and genetic drift)

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