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Lecture 10

Lecture 10 In-class Notes [Influenza]

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University of Toronto Scarborough
Health Studies
Caroline Barakat

Lecture 10 - Inuenza History - Hippocrates - record of an inuenza pandemic in the year 412 B.C. - Since 1580s, there ahve been 31 additional ue pandemics recorded - Spanish Flu (1918-1919) - Apprx. 50M deaths worldwide in less than 2 years - 500,000 death in the US (19,000 in NYC) - 300,000 cases in Ontario - 8700 death (1200 d in Tor. just 3 wks) - 500,000 cases and 14,000 deaths in Quebec Symptoms - Fever, chills, headache, weakness and fatigue as well as coughing, sneezing, runny nose (coryza) - residual cough and tiredness lasts up to 6 wks - complications can include ear infections, pneumonia, dehydration and death Etiology - 3 types of inuenza virus: inuenzaA(most virulent, B, & C - InuenzaAand C infect multiple species, while B almost only infect humans - InuenzaAvirus has 8 genes - New and virulent u strains are produced mainly from the effects of 2 surface proteins - Hemagglutinin (H) - critical to virus entry into cell - Neuraminidase (N) - allows virus to leave ho
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