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Lecture 11

Lecture 11 In-class Notes [Plagues w/out germs]

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Health Studies
Caroline Barakat

Lecture 11 - Plagues wout germs Dietary-decient diseases - Hidden Hunger - some date back to the 15th century - most are specic to the 19th century - time when the germ theorywon the battle - the quests in searching for the causes of nutrition-decient diseases was masked by the overwhelming condence in one germ, one diseasetheory Pellagra - Red plague - First described in Spain in 1735 - pelleagra Italian for skinrough - Appears rst as a skin rash; skin then crusts and peels away - Clinical symptoms 4Ds: dermatitis, diarrhea, dementia, and death - 1909 epidemic in US: reported in 26 states - 19th high fatality rates; e.g. 40% in SAmerica - 20 century 3M cases in the US and 100,000 deaths - Belief that pellagra was an infectious disease specic to the poor - By 1939 evidence established that disease was due to niacin-deciency (a water-soluble B vitamin vitamin B3) - Niacin needed for normal oxidative metabolism of sugars - lack of niacin implies sugars are not able to be metabolized - illness Beriberi - white riceplague - First described in 1616 as a neurological disorder characterized by paralysis of the hands and feet - Also named kakkemeaning leg disease - White rice - observed to be related to an increase in prevalence of beriberi - Ear
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