HLTB50H3 Lecture Notes - Lecture 9: Ctcf, Euchromatin, Xist (Gene)
Document Summary
Changes occur at the transcription level and translation level. Plasticity cells can respond differently to its environment. Gene code does not change, but environment influences gene expression. The methylation on the cytosine (at the promoter regions) can help prevent mutation. Certain genes are turned off in a sex dependent way. Genes in males are silenced whereas females are expressed. Igf2 is silenced in one chromosome but expressed in another. Ctcf binds to the insulator maternal chromosome is turned off. Methyl groups are added for the chromosome to be silenced. Insulator is always methylated on the maternal allele. In females, one x chromosome needs to be silenced. Histone core clusters of 4 histone. Imprinted genes insulin-like growth factor 2 (igf2) Histone tails modification is easy, cells quickly respond to environmental influences. Gender marker, dna methylation pro-longed response. Is just the modification and addition of the acetyl group. Connection of children with abuse and ptsd.
