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University of Toronto Scarborough
Janelle Leboutillier

Lecture 10 J The Hippocampus Video: W5 investigates intriguing new theory about MS N Patients with MS may have a brand new condition aggravatingcausing the disease N High level of toxic iron in brain tissue (causes inflammation and cell death) o BUT why is it there? N Uses ultrasound to scan heads and necks of MS patients N Evidence of narrowing of the vein in MS patients not draining out but flowing back up and depositing iron there N What happen if you open block vein? o Using balloons to repair malformed vein Hippocampus N 6 layers in neocortex What is Hippocampus? N Large amount of plasticity o Changes in the brain J makes it adaptable N Involved in declarative memory (regurgitation of facts) What is the HC susceptible to? N Alzheimer[s disease J problems with learning and memory and gets worse with time o Damage in HC N Highest seizure susceptibility N Lowest seizure threshold o More susceptible to seizure o Require less change for seizures to occur N Vulnerable to effects of ischemia and hypoxia o Ischemia (block blood flow to the brain J lack of oxygen, glucose) Location and Organization of HC and Dentate Gyrus N In temporal lobe J towards the base N Part of the limbic system N Hippocampal formation includes J larger structure encompasses: o Dentate gyrus, Hippocampus proper Hippocampus Pyramidal Cells N Primarily excitatory neurons N Effect threshold level www.notesolution.com
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