NROC61H3 Lecture Notes - Lecture 5: Microdialysis, Nucleus Accumbens, Model Organism
Document Summary
Midterm 1: why damage to fornix lead to less errors in win-stay task, dorsal striatum took over fornix and made dorsal striatum even better at s-r learning, believe this competition implemented in the cortico-striatal loops. Killcross and coutureau (2003: looked at how prelimbic vs infralimbic cortex lesions effect pre-training, then devaluated either food or sucrose via prefeeding and looked at how it. In context a, left lever press = food high level training (ie. trained a lot) Yin et al: looked closer at habit learning in dorsal striatum, splitting it into dorsolateral striatum (dls) and the dorsomedial striatum (dms, mice lever press for sucrose training to get. A-o learning: lever press in ratio schedules (not habitual training) for sucrose/pellet then prefeed to devalue it, then performed extinction test. Relevance to addiction: dopamine systems form ascending spiral of influence, start with medial nucleus accumbens and goes down to dls, form closed striato-nigrastriatal loops.
