NROC61H3 Lecture Notes - Lecture 6: Reuptake, Titration, Conditioned Place Preference
Document Summary
Central reward system: reward is measured by its hedonic impact, producing a feeling of pleasure after acts/experiences, there are 3 main experimental approaches for understanding the neural and neurochemical basis of reward. In intracranial self- stimulation (icss), animals work for electrical stimulation in certain areas of the brain: an electrode is implanted into specific areas of the brain and a pulse is sent to the brain. Icss positive sites: the medial forebrain bundle (mfb) is most important brain area for self- stimulation and reward. Neural mechanism of icss: the dopamine and noradrenaline pathways thought to play important roles in icss, later found that dopamine was important while the na pathways wasn"t too important. Final (non-cumulative: animals with functional nacc that received drug injection favoured context a over b seem to have learned that context a is rewarding, animals with nacc lesions show decreased preference.
